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BDBM50283468 CHEMBL4165785

SMILES: Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1c[nH]c(=O)c(c1)-c1ccc(Cl)cc1

InChI Key: InChIKey=SZDQAACPHGECGG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50283468   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Eukaryotic initiation factor 4A-III


(Homo sapiens (Human))		BDBM50283468
PNG
(CHEMBL4165785)
Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1c[nH]c(=O)c(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C29H22Cl3N3O3/c30-22-7-1-18(2-8-22)25-15-21(16-33-27(25)36)28(37)34-13-14-35(29(38)20-5-11-24(32)12-6-20)26(17-34)19-3-9-23(31)10-4-19/h1-12,15-16,26H,13-14,17H2,(H,33,36)
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UniProtKB/TrEMBL

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...

ACS Med Chem Lett 8: 1077-1082 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00283
BindingDB Entry DOI: 10.7270/Q2QJ7KT3
More data for this
Ligand-Target Pair