| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-III |
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| Ligand | BDBM50283468 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1725518 (CHEMBL4140796) |
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| IC50 | 1100±n/a nM |
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| Citation |  Mizojiri, R; Nakata, D; Satoh, Y; Morishita, D; Shibata, S; Iwatani-Yoshihara, M; Kosugi, Y; Kosaka, M; Takeda, J; Sasaki, S; Takami, K; Fukuda, K; Kamaura, M; Sasaki, S; Arai, R; Cary, DR; Imaeda, Y Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1 ACS Med Chem Lett8:1077-1082 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic initiation factor 4A-III |
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| Name: | Eukaryotic initiation factor 4A-III |
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| Synonyms: | ATP-dependent RNA helicase DDX48 | ATP-dependent RNA helicase eIF4A-3 | DDX48 | DEAD box protein 48 | EIF4A3 | Eukaryotic initiation factor 4A-like NUK-34 | Eukaryotic translation initiation factor 4A isoform 3 | IF4A3_HUMAN | KIAA0111 | NMP 265 | Nuclear matrix protein 265 | eIF-4A-III | eIF4A-III | hNMP 265 |
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| Type: | Protein |
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| Mol. Mass.: | 46871.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P38919 |
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| Residue: | 411 |
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| Sequence: | MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK
PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAV
QIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRA
IKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL
VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA
NFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL
YIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
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| BDBM50283468 |
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| n/a |
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| Name | BDBM50283468 |
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| Synonyms: | CHEMBL4165785 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H22Cl3N3O3 |
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| Mol. Mass. | 566.862 |
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| SMILES | Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1c[nH]c(=O)c(c1)-c1ccc(Cl)cc1 |
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| Structure | 
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