BDBM50283478 CHEMBL4164141

SMILES: COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F

InChI Key: InChIKey=CEQAJYFDDUETNM-UHFFFAOYSA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50283478   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50283478 (CHEMBL4164141) Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F |(37.17,-44.14,;38.18,-42.98,;37.7,-41.52,;38.73,-40.37,;38.23,-38.91,;39.26,-37.76,;36.73,-38.6,;35.71,-39.75,;36.19,-41.21,;35.16,-42.36,;36.25,-37.14,;37.15,-35.9,;38.69,-35.89,;36.24,-34.66,;34.78,-35.14,;33.45,-34.37,;32.12,-35.14,;32.12,-36.68,;30.79,-37.46,;33.45,-37.45,;34.79,-36.67,;33.45,-32.83,;34.79,-32.05,;32.12,-32.05,;33.44,-31.28,)| Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7) (Rattus norvegicus (Rat))	BDBM50283478 (CHEMBL4164141) Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F |(37.17,-44.14,;38.18,-42.98,;37.7,-41.52,;38.73,-40.37,;38.23,-38.91,;39.26,-37.76,;36.73,-38.6,;35.71,-39.75,;36.19,-41.21,;35.16,-42.36,;36.25,-37.14,;37.15,-35.9,;38.69,-35.89,;36.24,-34.66,;34.78,-35.14,;33.45,-34.37,;32.12,-35.14,;32.12,-36.68,;30.79,-37.46,;33.45,-37.45,;34.79,-36.67,;33.45,-32.83,;34.79,-32.05,;32.12,-32.05,;33.44,-31.28,)| Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	479	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50283478 (CHEMBL4164141) Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F |(37.17,-44.14,;38.18,-42.98,;37.7,-41.52,;38.73,-40.37,;38.23,-38.91,;39.26,-37.76,;36.73,-38.6,;35.71,-39.75,;36.19,-41.21,;35.16,-42.36,;36.25,-37.14,;37.15,-35.9,;38.69,-35.89,;36.24,-34.66,;34.78,-35.14,;33.45,-34.37,;32.12,-35.14,;32.12,-36.68,;30.79,-37.46,;33.45,-37.45,;34.79,-36.67,;33.45,-32.83,;34.79,-32.05,;32.12,-32.05,;33.44,-31.28,)| Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	490	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50283478 (CHEMBL4164141) Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F |(37.17,-44.14,;38.18,-42.98,;37.7,-41.52,;38.73,-40.37,;38.23,-38.91,;39.26,-37.76,;36.73,-38.6,;35.71,-39.75,;36.19,-41.21,;35.16,-42.36,;36.25,-37.14,;37.15,-35.9,;38.69,-35.89,;36.24,-34.66,;34.78,-35.14,;33.45,-34.37,;32.12,-35.14,;32.12,-36.68,;30.79,-37.46,;33.45,-37.45,;34.79,-36.67,;33.45,-32.83,;34.79,-32.05,;32.12,-32.05,;33.44,-31.28,)| Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	490	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50283478 (CHEMBL4164141) Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F |(37.17,-44.14,;38.18,-42.98,;37.7,-41.52,;38.73,-40.37,;38.23,-38.91,;39.26,-37.76,;36.73,-38.6,;35.71,-39.75,;36.19,-41.21,;35.16,-42.36,;36.25,-37.14,;37.15,-35.9,;38.69,-35.89,;36.24,-34.66,;34.78,-35.14,;33.45,-34.37,;32.12,-35.14,;32.12,-36.68,;30.79,-37.46,;33.45,-37.45,;34.79,-36.67,;33.45,-32.83,;34.79,-32.05,;32.12,-32.05,;33.44,-31.28,)| Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	<3.16E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7) (Rattus norvegicus (Rat))	BDBM50283478 (CHEMBL4164141) Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F |(37.17,-44.14,;38.18,-42.98,;37.7,-41.52,;38.73,-40.37,;38.23,-38.91,;39.26,-37.76,;36.73,-38.6,;35.71,-39.75,;36.19,-41.21,;35.16,-42.36,;36.25,-37.14,;37.15,-35.9,;38.69,-35.89,;36.24,-34.66,;34.78,-35.14,;33.45,-34.37,;32.12,-35.14,;32.12,-36.68,;30.79,-37.46,;33.45,-37.45,;34.79,-36.67,;33.45,-32.83,;34.79,-32.05,;32.12,-32.05,;33.44,-31.28,)| Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	480	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair