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BDBM50284976 1-[1-(2-Chloro-phenyl)-1H-benzoimidazol-2-yl]-3-(2,6-diisopropyl-phenyl)-urea::CHEMBL52678

SMILES: CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1ccccc1Cl

InChI Key: InChIKey=HTIVQRSGBOUPBD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50284976   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50284976
PNG
(1-[1-(2-Chloro-phenyl)-1H-benzoimidazol-2-yl]-3-(2...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1ccccc1Cl |(20.07,-7.3,;18.53,-7.31,;17.78,-8.64,;17.76,-5.98,;18.53,-4.64,;17.76,-3.31,;16.2,-3.32,;15.45,-4.67,;13.91,-4.67,;13.12,-3.34,;12.42,-5.07,;16.22,-5.98,;15.47,-7.33,;13.93,-7.33,;13.14,-6,;13.17,-8.66,;11.63,-8.68,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,;10.72,-9.92,;10.72,-11.46,;12.02,-12.23,;12.02,-13.77,;10.69,-14.54,;9.36,-13.75,;9.36,-12.23,;8.05,-11.44,)|
Show InChI InChI=1S/C26H27ClN4O/c1-16(2)18-10-9-11-19(17(3)4)24(18)29-26(32)30-25-28-21-13-6-8-15-23(21)31(25)22-14-7-5-12-20(22)27/h5-17H,1-4H3,(H2,28,29,30,32)
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Article
n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards acyl CoA cholesterol acyltransferase (ACAT) of cholesterol-fed rabbits by the displacement of [14C]-oleolyl-CoA

Bioorg Med Chem Lett 5: 1829-1832 (1995)


Article DOI: 10.1016/0960-894X(95)00296-6
BindingDB Entry DOI: 10.7270/Q2VD6ZDR
More data for this
Ligand-Target Pair