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BDBM50287952 CHEMBL304717::N-{4-[(2S,6R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(4-chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-morpholine-4-sulfonyl]-phenyl}-acetamide

SMILES: COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO[Si](C)(C)C(C)(C)C)O1)S(=O)(=O)c1ccc(NC(C)=O)cc1

InChI Key: InChIKey=HFIYWZSTTKASLB-WNCULLNHSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50287952   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GTPase HRas


(Homo sapiens (Human))
BDBM50287952
PNG
(CHEMBL304717 | N-{4-[(2S,6R)-2-(tert-Butyl-dimethy...)
Show SMILES COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO[Si](C)(C)C(C)(C)C)O1)S(=O)(=O)c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C31H40ClN5O6SSi/c1-19-28-29(32)25-15-22(41-6)11-14-26(25)34-30(28)37(35-19)27-17-36(16-23(43-27)18-42-45(7,8)31(3,4)5)44(39,40)24-12-9-21(10-13-24)33-20(2)38/h9-15,23,27H,16-18H2,1-8H3,(H,33,38)/t23-,27+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 2.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of nucleotide exchange process of oncogenic Ras in vitro


Bioorg Med Chem Lett 6: 195-200 (1996)


Article DOI: 10.1016/0960-894X(95)00574-D
BindingDB Entry DOI: 10.7270/Q2G160TB
More data for this
Ligand-Target Pair