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BDBM50287958 CHEMBL303105::[(2S,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitro-benzenesulfonyl)-morpholin-2-yl]-methanol

SMILES: COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO)O1)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O

InChI Key: InChIKey=WPOZWGIQCBBWTI-OXJNMPFZSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50287958   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GTPase HRas


(Homo sapiens (Human))
BDBM50287958
PNG
(CHEMBL303105 | [(2S,6R)-6-(4-Chloro-6-methoxy-3-me...)
Show SMILES COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@H]1CN(C[C@@H](CO)O1)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C23H22ClN5O7S/c1-13-21-22(24)18-9-15(35-2)5-8-19(18)25-23(21)28(26-13)20-11-27(10-16(12-30)36-20)37(33,34)17-6-3-14(4-7-17)29(31)32/h3-9,16,20,30H,10-12H2,1-2H3/t16-,20+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of nucleotide exchange process of oncogenic Ras in vitro


Bioorg Med Chem Lett 6: 195-200 (1996)


Article DOI: 10.1016/0960-894X(95)00574-D
BindingDB Entry DOI: 10.7270/Q2G160TB
More data for this
Ligand-Target Pair