BDBM50288818 (R)-4-[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluoro-biphenyl-4-yl)-1-methyl-propylcarbamoyl]-3-methyl-butyric acid::CHEMBL356514

SMILES: C[C@@H](CC(O)=O)CC(=O)N[C@@H](C)[C@@H](Cc1ccc(Cl)c(Cl)c1)c1ccc(c(F)c1)-c1ccccc1

InChI Key: InChIKey=QZWRZJBKAUEGBI-IEGUWTFLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50288818   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Squalene synthetase (Homo sapiens (Human))	BDBM50288818 ((R)-4-[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluoro...) Show SMILES C[C@@H](CC(O)=O)CC(=O)N[C@@H](C)[C@@H](Cc1ccc(Cl)c(Cl)c1)c1ccc(c(F)c1)-c1ccccc1 Show InChI InChI=1S/C28H28Cl2FNO3/c1-17(13-28(34)35)12-27(33)32-18(2)23(14-19-8-11-24(29)25(30)15-19)21-9-10-22(26(31)16-21)20-6-4-3-5-7-20/h3-11,15-18,23H,12-14H2,1-2H3,(H,32,33)(H,34,35)/t17-,18+,23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity of the compound against squalene synthase (SQS) obtained from HepG2 cells				Bioorg Med Chem Lett 6: 463-466 (1996) Article DOI: 10.1016/0960-894X(96)00033-9 BindingDB Entry DOI: 10.7270/Q2MG7PG7
					More data for this Ligand-Target Pair