BDBM50290086 (R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)-propyl]-N*4*-hydroxy-2-isobutyl-succinamide::CHEMBL306412::Ro-37-9790

SMILES: CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)CC(=O)NO)C(C)(C)C

InChI Key: InChIKey=QRXOZHSEEGNRFC-PWSUYJOCSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50290086   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50290086 ((R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)-pro...) Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)CC(=O)NO)C(C)(C)C Show InChI InChI=1S/C15H29N3O4/c1-9(2)7-10(8-11(19)18-22)13(20)17-12(14(21)16-6)15(3,4)5/h9-10,12,22H,7-8H2,1-6H3,(H,16,21)(H,17,20)(H,18,19)/t10-,12+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human gelatinase B, MMP9				Bioorg Med Chem Lett 7: 2299-2302 (1997) Article DOI: 10.1016/S0960-894X(97)00416-2 BindingDB Entry DOI: 10.7270/Q26T0MM8
					More data for this Ligand-Target Pair
Collagenase (Homo sapiens (Human))	BDBM50290086 ((R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)-pro...) Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)CC(=O)NO)C(C)(C)C Show InChI InChI=1S/C15H29N3O4/c1-9(2)7-10(8-11(19)18-22)13(20)17-12(14(21)16-6)15(3,4)5/h9-10,12,22H,7-8H2,1-6H3,(H,16,21)(H,17,20)(H,18,19)/t10-,12+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)				Bioorg Med Chem Lett 7: 2299-2302 (1997) Article DOI: 10.1016/S0960-894X(97)00416-2 BindingDB Entry DOI: 10.7270/Q26T0MM8
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50290086 ((R)-N*1*-[2,2-Dimethyl-1-((R)-methylcarbamoyl)-pro...) Show SMILES CNC(=O)[C@H](NC(=O)[C@H](CC(C)C)CC(=O)NO)C(C)(C)C Show InChI InChI=1S/C15H29N3O4/c1-9(2)7-10(8-11(19)18-22)13(20)17-12(14(21)16-6)15(3,4)5/h9-10,12,22H,7-8H2,1-6H3,(H,16,21)(H,17,20)(H,18,19)/t10-,12+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human stromelysin-1, MMP-3				Bioorg Med Chem Lett 7: 2299-2302 (1997) Article DOI: 10.1016/S0960-894X(97)00416-2 BindingDB Entry DOI: 10.7270/Q26T0MM8
					More data for this Ligand-Target Pair