BDBM50290417 2-Amino-pyrimidine, 19::CHEMBL418270::N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-nicotinamide

SMILES: O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccnc1

InChI Key: InChIKey=QOFWWNRCEIPMLU-UHFFFAOYSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50290417   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen Synthase Kinase 3 (GSK3) (Ustilago maydis (Smut fungus))	BDBM50290417 (2-Amino-pyrimidine, 19 | CHEMBL418270 | N-[3-(4-Py...) Show SMILES O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccnc1 Show InChI InChI=1S/C21H16N6O/c28-20(16-5-3-10-23-14-16)25-17-6-1-7-18(12-17)26-21-24-11-8-19(27-21)15-4-2-9-22-13-15/h1-14H,(H,25,28)(H,24,26,27)	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universität Dortmund					Assay Description Inhibition of UmGSK3 by kinase inhibitors.				ACS Chem Biol 7: 1257-67 (2012) Article DOI: 10.1021/cb300128b BindingDB Entry DOI: 10.7270/Q29S1PNH
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50290417 (2-Amino-pyrimidine, 19 | CHEMBL418270 | N-[3-(4-Py...) Show SMILES O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccnc1 Show InChI InChI=1S/C21H16N6O/c28-20(16-5-3-10-23-14-16)25-17-6-1-7-18(12-17)26-21-24-11-8-19(27-21)15-4-2-9-22-13-15/h1-14H,(H,25,28)(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universität Dortmund					Assay Description Inhibition of UmGSK3 by kinase inhibitors.				ACS Chem Biol 7: 1257-67 (2012) Article DOI: 10.1021/cb300128b BindingDB Entry DOI: 10.7270/Q29S1PNH
					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50290417 (2-Amino-pyrimidine, 19 | CHEMBL418270 | N-[3-(4-Py...) Show SMILES O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccnc1 Show InChI InChI=1S/C21H16N6O/c28-20(16-5-3-10-23-14-16)25-17-6-1-7-18(12-17)26-21-24-11-8-19(27-21)15-4-2-9-22-13-15/h1-14H,(H,25,28)(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of protein kinase C alpha.				Bioorg Med Chem Lett 7: 187-192 (1997) Article DOI: 10.1016/S0960-894X(96)00601-4 BindingDB Entry DOI: 10.7270/Q23X86MF
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50290417 (2-Amino-pyrimidine, 19 | CHEMBL418270 | N-[3-(4-Py...) Show SMILES O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccnc1 Show InChI InChI=1S/C21H16N6O/c28-20(16-5-3-10-23-14-16)25-17-6-1-7-18(12-17)26-21-24-11-8-19(27-21)15-4-2-9-22-13-15/h1-14H,(H,25,28)(H,24,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of the epidermal growth factor receptor.				Bioorg Med Chem Lett 7: 187-192 (1997) Article DOI: 10.1016/S0960-894X(96)00601-4 BindingDB Entry DOI: 10.7270/Q23X86MF
					More data for this Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50290417 (2-Amino-pyrimidine, 19 | CHEMBL418270 | N-[3-(4-Py...) Show SMILES O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccnc1 Show InChI InChI=1S/C21H16N6O/c28-20(16-5-3-10-23-14-16)25-17-6-1-7-18(12-17)26-21-24-11-8-19(27-21)15-4-2-9-22-13-15/h1-14H,(H,25,28)(H,24,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of the platelet-derived growth factor receptor.				Bioorg Med Chem Lett 7: 187-192 (1997) Article DOI: 10.1016/S0960-894X(96)00601-4 BindingDB Entry DOI: 10.7270/Q23X86MF
					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50290417 (2-Amino-pyrimidine, 19 | CHEMBL418270 | N-[3-(4-Py...) Show SMILES O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccnc1 Show InChI InChI=1S/C21H16N6O/c28-20(16-5-3-10-23-14-16)25-17-6-1-7-18(12-17)26-21-24-11-8-19(27-21)15-4-2-9-22-13-15/h1-14H,(H,25,28)(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of protein kinase C delta.				Bioorg Med Chem Lett 7: 187-192 (1997) Article DOI: 10.1016/S0960-894X(96)00601-4 BindingDB Entry DOI: 10.7270/Q23X86MF
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50290417 (2-Amino-pyrimidine, 19 | CHEMBL418270 | N-[3-(4-Py...) Show SMILES O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccnc1 Show InChI InChI=1S/C21H16N6O/c28-20(16-5-3-10-23-14-16)25-17-6-1-7-18(12-17)26-21-24-11-8-19(27-21)15-4-2-9-22-13-15/h1-14H,(H,25,28)(H,24,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of c-Src-tyrosine kinase.				Bioorg Med Chem Lett 7: 187-192 (1997) Article DOI: 10.1016/S0960-894X(96)00601-4 BindingDB Entry DOI: 10.7270/Q23X86MF
					More data for this Ligand-Target Pair
Bcr-Abl (Homo sapiens (Human))	BDBM50290417 (2-Amino-pyrimidine, 19 | CHEMBL418270 | N-[3-(4-Py...) Show SMILES O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccnc1 Show InChI InChI=1S/C21H16N6O/c28-20(16-5-3-10-23-14-16)25-17-6-1-7-18(12-17)26-21-24-11-8-19(27-21)15-4-2-9-22-13-15/h1-14H,(H,25,28)(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	151	n/a	n/a	n/a	n/a	n/a	n/a
The First People's Hospital of Hangzhou Curated by ChEMBL					Assay Description Inhibition of BCR-ABL kinase (unknown origin)				Bioorg Med Chem Lett 23: 2442-50 (2013) Article DOI: 10.1016/j.bmcl.2013.01.113 BindingDB Entry DOI: 10.7270/Q2ZG6TMD
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase (PKA) (Homo sapiens (Human))	BDBM50290417 (2-Amino-pyrimidine, 19 | CHEMBL418270 | N-[3-(4-Py...) Show SMILES O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccnc1 Show InChI InChI=1S/C21H16N6O/c28-20(16-5-3-10-23-14-16)25-17-6-1-7-18(12-17)26-21-24-11-8-19(27-21)15-4-2-9-22-13-15/h1-14H,(H,25,28)(H,24,26,27)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of the platelet-derived growth factor receptor.				Bioorg Med Chem Lett 7: 187-192 (1997) Article DOI: 10.1016/S0960-894X(96)00601-4 BindingDB Entry DOI: 10.7270/Q23X86MF
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50290417 (2-Amino-pyrimidine, 19 | CHEMBL418270 | N-[3-(4-Py...) Show SMILES O=C(Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1)c1cccnc1 Show InChI InChI=1S/C21H16N6O/c28-20(16-5-3-10-23-14-16)25-17-6-1-7-18(12-17)26-21-24-11-8-19(27-21)15-4-2-9-22-13-15/h1-14H,(H,25,28)(H,24,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of v-Abl tyrosine kinase.				Bioorg Med Chem Lett 7: 187-192 (1997) Article DOI: 10.1016/S0960-894X(96)00601-4 BindingDB Entry DOI: 10.7270/Q23X86MF
					More data for this Ligand-Target Pair