BindingDB PrimarySearch

BDBM50291979 CHEMBL176602::N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID::N-hydroxy-2(R)-[[(R)-methylphenylphosphinyl]-benzylamino]-4-methylpentanamide

SMILES: CC(C)C[C@@H](N(Cc1ccccc1)[P@](C)(=O)c1ccccc1)C(=O)NO

InChI Key: InChIKey=KGUVBHLPMGERAT-NIYFSFCBSA-N

Data: 7 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50291979
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50291979 (CHEMBL176602 \| N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human matrix metalloprotease 2				J Med Chem 42: 87-94 (1999) Article DOI: 10.1021/jm980142s BindingDB Entry DOI: 10.7270/Q2FF3T1N
Procter and Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50291979 (CHEMBL176602 \| N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human matrix metalloprotease 9				J Med Chem 42: 87-94 (1999) Article DOI: 10.1021/jm980142s BindingDB Entry DOI: 10.7270/Q2FF3T1N
Procter and Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7) (Homo sapiens (Human))	BDBM50291979 (CHEMBL176602 \| N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	886	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human matrix metalloprotease 7				J Med Chem 42: 87-94 (1999) Article DOI: 10.1021/jm980142s BindingDB Entry DOI: 10.7270/Q2FF3T1N
Procter and Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase 13 (Rattus norvegicus)	BDBM50291979 (CHEMBL176602 \| N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of rat matrix metalloprotease 13				J Med Chem 42: 87-94 (1999) Article DOI: 10.1021/jm980142s BindingDB Entry DOI: 10.7270/Q2FF3T1N
Procter and Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50291979 (CHEMBL176602 \| N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human Matrix metalloprotease-8				J Med Chem 42: 87-94 (1999) Article DOI: 10.1021/jm980142s BindingDB Entry DOI: 10.7270/Q2FF3T1N
Procter and Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50291979 (CHEMBL176602 \| N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human matrix metalloprotease-3				J Med Chem 42: 87-94 (1999) Article DOI: 10.1021/jm980142s BindingDB Entry DOI: 10.7270/Q2FF3T1N
Procter and Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50291979 (CHEMBL176602 \| N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Procter and Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human matrix metalloprotease 1				J Med Chem 42: 87-94 (1999) Article DOI: 10.1021/jm980142s BindingDB Entry DOI: 10.7270/Q2FF3T1N
Procter and Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair