BindingDB PrimarySearch

BDBM50292408 (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)glycine::5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acid::CHEMBL288943::LTD4::S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteinylglycine::leukotriene D4

SMILES: CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O

InChI Key: InChIKey=YEESKJGWJFYOOK-IJHYULJSSA-N

Data: 6 KI 2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50292408
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Renal dipeptidase (GUINEA PIG)	BDBM50292408 ((R-(R,S-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxy...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	0.490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by PDSP K_i Database									J Pharmacol Exp Ther 258: 531-6 (1991) BindingDB Entry DOI: 10.7270/Q2BK19TF
Pfizer Inc. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 2 (GUINEA PIG)	BDBM50292408 ((R-(R,S-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxy...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	0.490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by PDSP K_i Database									J Pharmacol Exp Ther 258: 531-6 (1991) BindingDB Entry DOI: 10.7270/Q2BK19TF
Pfizer Inc. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor (Homo sapiens (Human))	BDBM50292408 ((R-(R,S-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]LTD4 from LTD4 receptor				J Nat Prod 56: 441-455 (1993) Article DOI: 10.1021/np50094a001 BindingDB Entry DOI: 10.7270/Q2VT1S4B
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Leukotriene 2 (Homo sapiens (Human))	BDBM50292408 ((R-(R,S-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxy...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.48	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Virginia Curated by PDSP K_i Database									J Biol Chem 275: 30531-6 (2000) Article DOI: 10.1074/jbc.M003490200 BindingDB Entry DOI: 10.7270/Q2BP01BH
University of Virginia Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Leukotriene B4 receptor (Homo sapiens (Human))	BDBM50292408 ((R-(R,S-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by PDSP K_i Database									J Biol Chem 275: 40686-94 (2000) Article DOI: 10.1074/jbc.M004512200 BindingDB Entry DOI: 10.7270/Q2XD1066
					More data for this Ligand-Target Pair
Leukotriene 2 (Homo sapiens (Human))	BDBM50292408 ((R-(R,S-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxy...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by PDSP K_i Database									J Biol Chem 275: 40686-94 (2000) Article DOI: 10.1074/jbc.M004512200 BindingDB Entry DOI: 10.7270/Q2XD1066
					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 1 (Rattus norvegicus)	BDBM50292408 ((R-(R,S-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxy...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells				Mol Pharmacol 59: 1077-85 (2001) Article DOI: 10.1124/mol.59.5.1077 BindingDB Entry DOI: 10.7270/Q2348P8T
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor (Homo sapiens (Human))	BDBM50292408 ((R-(R,S-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human leukotriene D4 receptor				Bioorg Med Chem 18: 7675-99 (2010) Article DOI: 10.1016/j.bmc.2010.07.034 BindingDB Entry DOI: 10.7270/Q2DF6S69
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair