BDBM50292738 CHEMBL472942::N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinolin-6-yl)-4-morpholinobut-2-enamide

SMILES: COc1cc2nccc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCOCC1

InChI Key: InChIKey=NRDFOMRXSXXTEM-NSCUHMNNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50292738   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50292738 (CHEMBL472942 | N-(4-(3-chloro-4-fluorophenylamino)...) Show SMILES COc1cc2nccc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCOCC1 Show InChI InChI=1S/C24H24ClFN4O3/c1-32-23-15-21-17(20(6-7-27-21)28-16-4-5-19(26)18(25)13-16)14-22(23)29-24(31)3-2-8-30-9-11-33-12-10-30/h2-7,13-15H,8-12H2,1H3,(H,27,28)(H,29,31)/b3-2+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of human recombinant EGFR				J Med Chem 52: 964-75 (2009) Article DOI: 10.1021/jm800829v BindingDB Entry DOI: 10.7270/Q27W6C7Q
					More data for this Ligand-Target Pair