BDBM50293081 7-({[(2R)-2,3-Dihydroxypropyl](2-hydroxyethyl)amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL445029

SMILES: OCCN(C[C@H](O)CO)Cc1c[nH]c2c1nc[nH]c2=O

InChI Key: InChIKey=LNNMXGVBXFJDJN-VIFPVBQESA-N

Data: 1 KI  2 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50293081   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50293081 (7-({[(2R)-2,3-Dihydroxypropyl](2-hydroxyethyl)amin...) Show SMILES OCCN(C[C@H](O)CO)Cc1c[nH]c2c1nc[nH]c2=O |r| Show InChI InChI=1S/C12H18N4O4/c17-2-1-16(5-9(19)6-18)4-8-3-13-11-10(8)14-7-15-12(11)20/h3,7,9,13,17-19H,1-2,4-6H2,(H,14,15,20)/t9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.65E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Industrial Research Limited Curated by ChEMBL					Assay Description Inhibition of human PNP by xanthine-oxidase coupled assay				J Med Chem 52: 1126-43 (2009) Article DOI: 10.1021/jm801421q BindingDB Entry DOI: 10.7270/Q2QR4Z18
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50293081 (7-({[(2R)-2,3-Dihydroxypropyl](2-hydroxyethyl)amin...) Show SMILES OCCN(C[C@H](O)CO)Cc1c[nH]c2c1nc[nH]c2=O |r| Show InChI InChI=1S/C12H18N4O4/c17-2-1-16(5-9(19)6-18)4-8-3-13-11-10(8)14-7-15-12(11)20/h3,7,9,13,17-19H,1-2,4-6H2,(H,14,15,20)/t9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	96	n/a	n/a	n/a	n/a	25
Industrial Research Limited; Albert Einstein College of Medicine of Yeshiva University US Patent					Assay Description The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...				US Patent US8853224 (2014) BindingDB Entry DOI: 10.7270/Q27H1H84
					More data for this Ligand-Target Pair
Purine Nucleoside Phosphorylase (PNP) (Plasmodium falciparum)	BDBM50293081 (7-({[(2R)-2,3-Dihydroxypropyl](2-hydroxyethyl)amin...) Show SMILES OCCN(C[C@H](O)CO)Cc1c[nH]c2c1nc[nH]c2=O |r| Show InChI InChI=1S/C12H18N4O4/c17-2-1-16(5-9(19)6-18)4-8-3-13-11-10(8)14-7-15-12(11)20/h3,7,9,13,17-19H,1-2,4-6H2,(H,14,15,20)/t9-/m0/s1	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	25
Industrial Research Limited; Albert Einstein College of Medicine of Yeshiva University US Patent					Assay Description The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...				US Patent US8853224 (2014) BindingDB Entry DOI: 10.7270/Q27H1H84
					More data for this Ligand-Target Pair