BDBM50293155 CHEMBL497564::N-(3-(oxazol-4-yl)phenyl)-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine

SMILES: N(c1cccc(c1)-c1cocn1)c1nccc(n1)-c1cnn2ncccc12

InChI Key: InChIKey=AKEMXASAMBDUOC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50293155   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM50293155 (CHEMBL497564 | N-(3-(oxazol-4-yl)phenyl)-4-(pyrazo...) Show SMILES N(c1cccc(c1)-c1cocn1)c1nccc(n1)-c1cnn2ncccc12 Show InChI InChI=1S/C19H13N7O/c1-3-13(17-11-27-12-21-17)9-14(4-1)24-19-20-8-6-16(25-19)15-10-23-26-18(15)5-2-7-22-26/h1-12H,(H,20,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of CDK4 by radioactive glutathione plate-binding assay				Bioorg Med Chem Lett 18: 5758-62 (2009) Article DOI: 10.1016/j.bmcl.2008.09.069 BindingDB Entry DOI: 10.7270/Q2J67GZN
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50293155 (CHEMBL497564 | N-(3-(oxazol-4-yl)phenyl)-4-(pyrazo...) Show SMILES N(c1cccc(c1)-c1cocn1)c1nccc(n1)-c1cnn2ncccc12 Show InChI InChI=1S/C19H13N7O/c1-3-13(17-11-27-12-21-17)9-14(4-1)24-19-20-8-6-16(25-19)15-10-23-26-18(15)5-2-7-22-26/h1-12H,(H,20,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human CDK2 by HTRF assay				Bioorg Med Chem Lett 18: 5758-62 (2009) Article DOI: 10.1016/j.bmcl.2008.09.069 BindingDB Entry DOI: 10.7270/Q2J67GZN
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50293155 (CHEMBL497564 | N-(3-(oxazol-4-yl)phenyl)-4-(pyrazo...) Show SMILES N(c1cccc(c1)-c1cocn1)c1nccc(n1)-c1cnn2ncccc12 Show InChI InChI=1S/C19H13N7O/c1-3-13(17-11-27-12-21-17)9-14(4-1)24-19-20-8-6-16(25-19)15-10-23-26-18(15)5-2-7-22-26/h1-12H,(H,20,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of GSK3beta by scintillation proximity assay				Bioorg Med Chem Lett 18: 5758-62 (2009) Article DOI: 10.1016/j.bmcl.2008.09.069 BindingDB Entry DOI: 10.7270/Q2J67GZN
					More data for this Ligand-Target Pair