Found 14 hits for monomerid = 50293361 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histone deacetylase 2
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this Ligand-Target Pair | |
Cereblon/Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of human HDAC6 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this Ligand-Target Pair | |
Histone deacetylase 9
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of human HDAC9 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this Ligand-Target Pair | |
Histone deacetylase 8
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of human HDAC8 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this Ligand-Target Pair | |
Histone deacetylase 11
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of human HDAC11 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this Ligand-Target Pair | |
Histone deacetylase 3
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of human HDAC3 complexed with NCOR2 using fluorogenic tetrapeptide RHKKAc as susbtrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this Ligand-Target Pair | |
Histone deacetylase 2
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of HDAC2 in human HeLa cells |
Eur J Med Chem 44: 1900-12 (2009)
Article DOI: 10.1016/j.ejmech.2008.11.005 BindingDB Entry DOI: 10.7270/Q2M045G2 |
More data for this Ligand-Target Pair | |
Histone deacetylase 10
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this Ligand-Target Pair | |
Histone deacetylase 4
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of human HDAC4 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this Ligand-Target Pair | |
Histone deacetylase 7
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of human HDAC7 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this Ligand-Target Pair | |
Histone deacetylase 5
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of human HDAC5 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milan
Curated by ChEMBL
| Assay Description Inhibition of HDAC in human HeLa cells using BOC-Ac-Lys-AMC as substrate incubated for 4 hrs by fluorescence assay |
Eur J Med Chem 112: 99-105 (2016)
BindingDB Entry DOI: 10.7270/Q2HM5BB0 |
More data for this Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milan
Curated by ChEMBL
| Assay Description Inhibition of HDAC in human HeLa nuclear extract using BOC-Ac-Lys-AMC as substrate incubated for 90 mins by fluorescence assay |
Eur J Med Chem 112: 99-105 (2016)
BindingDB Entry DOI: 10.7270/Q2HM5BB0 |
More data for this Ligand-Target Pair | |
Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of human HDAC1 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this Ligand-Target Pair | |