BDBM50293910 (S)-5-chloro-1-(1-cyclopropylethyl)-3-(2,6-dichloro-4-(difluoromethoxy)phenylamino)pyrazin-2(1H)-one::CHEMBL562219

SMILES: C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O

InChI Key: InChIKey=NFRNVFLIULAQST-ZETCQYMHSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50293910   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor (Rattus norvegicus (rat))	BDBM50293910 ((S)-5-chloro-1-(1-cyclopropylethyl)-3-(2,6-dichlor...) Show SMILES C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O |r| Show InChI InChI=1S/C16H14Cl3F2N3O2/c1-7(8-2-3-8)24-6-12(19)22-14(15(24)25)23-13-10(17)4-9(5-11(13)18)26-16(20)21/h4-8,16H,2-3H2,1H3,(H,22,23)/t7-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique				J Med Chem 52: 4161-72 (2009) Article DOI: 10.1021/jm900302q BindingDB Entry DOI: 10.7270/Q2WW7JM0
					More data for this Ligand-Target Pair
Corticotropin releasing hormone receptor 2 (Sus scrofa)	BDBM50293910 ((S)-5-chloro-1-(1-cyclopropylethyl)-3-(2,6-dichlor...) Show SMILES C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O |r| Show InChI InChI=1S/C16H14Cl3F2N3O2/c1-7(8-2-3-8)24-6-12(19)22-14(15(24)25)23-13-10(17)4-9(5-11(13)18)26-16(20)21/h4-8,16H,2-3H2,1H3,(H,22,23)/t7-/m0/s1	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from CRF2 receptor in pig choroid plexus by rapid filtration technique				J Med Chem 52: 4161-72 (2009) Article DOI: 10.1021/jm900302q BindingDB Entry DOI: 10.7270/Q2WW7JM0
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50293910 ((S)-5-chloro-1-(1-cyclopropylethyl)-3-(2,6-dichlor...) Show SMILES C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O |r| Show InChI InChI=1S/C16H14Cl3F2N3O2/c1-7(8-2-3-8)24-6-12(19)22-14(15(24)25)23-13-10(17)4-9(5-11(13)18)26-16(20)21/h4-8,16H,2-3H2,1H3,(H,22,23)/t7-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Antagonist activity at CRF1 receptor in human Y-79 cells assessed as inhibition of CRF-induced cAMP production after 30 mins by HTRF analysis				J Med Chem 52: 4161-72 (2009) Article DOI: 10.1021/jm900302q BindingDB Entry DOI: 10.7270/Q2WW7JM0
					More data for this Ligand-Target Pair