BDBM50294218 (3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-2,2-dimethylchroman-4-ylamino)ethyl)-3,4,14-trimethyl-1,4-diazacyclohexadecane-2,5-dione::CHEMBL558488
SMILES: CC(C)c1ccc2OC(C)(C)C[C@H](NC[C@@H](O)[C@@H]3C[C@H](C)CCCCCCCCC(=O)N(C)[C@@H](C)C(=O)N3)c2c1
InChI Key: InChIKey=MNENNUUKHSBOKZ-BEOVBFIISA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM50294218 ((3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregation | Bioorg Med Chem Lett 19: 1366-70 (2009) Article DOI: 10.1016/j.bmcl.2009.01.055 BindingDB Entry DOI: 10.7270/Q2SB45S3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin D (Homo sapiens (Human)) | BDBM50294218 ((3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human cathepsin D | Bioorg Med Chem Lett 19: 1366-70 (2009) Article DOI: 10.1016/j.bmcl.2009.01.055 BindingDB Entry DOI: 10.7270/Q2SB45S3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM50294218 ((3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of BACE1 | Bioorg Med Chem Lett 19: 1366-70 (2009) Article DOI: 10.1016/j.bmcl.2009.01.055 BindingDB Entry DOI: 10.7270/Q2SB45S3 | |||||||||||
More data for this Ligand-Target Pair |