Found 11 hits for monomerid = 50294271 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50294271
(5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-...)Show InChI InChI=1S/C18H20Cl2N2O/c1-12-5-6-14(11-22-12)18(13-7-9-21-10-8-13)23-16-4-2-3-15(19)17(16)20/h2-6,11,13,18,21H,7-10H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2829-34 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.090 BindingDB Entry DOI: 10.7270/Q2HX1CQX |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50294271
(5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-...)Show InChI InChI=1S/C18H20Cl2N2O/c1-12-5-6-14(11-22-12)18(13-7-9-21-10-8-13)23-16-4-2-3-15(19)17(16)20/h2-6,11,13,18,21H,7-10H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2829-34 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.090 BindingDB Entry DOI: 10.7270/Q2HX1CQX |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50294271
(5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-...)Show InChI InChI=1S/C18H20Cl2N2O/c1-12-5-6-14(11-22-12)18(13-7-9-21-10-8-13)23-16-4-2-3-15(19)17(16)20/h2-6,11,13,18,21H,7-10H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2829-34 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.090 BindingDB Entry DOI: 10.7270/Q2HX1CQX |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50294271
(5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-...)Show InChI InChI=1S/C18H20Cl2N2O/c1-12-5-6-14(11-22-12)18(13-7-9-21-10-8-13)23-16-4-2-3-15(19)17(16)20/h2-6,11,13,18,21H,7-10H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2829-34 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.090 BindingDB Entry DOI: 10.7270/Q2HX1CQX |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50294271
(5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-...)Show InChI InChI=1S/C18H20Cl2N2O/c1-12-5-6-14(11-22-12)18(13-7-9-21-10-8-13)23-16-4-2-3-15(19)17(16)20/h2-6,11,13,18,21H,7-10H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2829-34 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.090 BindingDB Entry DOI: 10.7270/Q2HX1CQX |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50294271
(5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-...)Show InChI InChI=1S/C18H20Cl2N2O/c1-12-5-6-14(11-22-12)18(13-7-9-21-10-8-13)23-16-4-2-3-15(19)17(16)20/h2-6,11,13,18,21H,7-10H2,1H3 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of CYP2D6 |
Bioorg Med Chem Lett 19: 2829-34 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.090 BindingDB Entry DOI: 10.7270/Q2HX1CQX |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50294271
(5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-...)Show InChI InChI=1S/C18H20Cl2N2O/c1-12-5-6-14(11-22-12)18(13-7-9-21-10-8-13)23-16-4-2-3-15(19)17(16)20/h2-6,11,13,18,21H,7-10H2,1H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2829-34 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.090 BindingDB Entry DOI: 10.7270/Q2HX1CQX |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50294271
(5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-...)Show InChI InChI=1S/C18H20Cl2N2O/c1-12-5-6-14(11-22-12)18(13-7-9-21-10-8-13)23-16-4-2-3-15(19)17(16)20/h2-6,11,13,18,21H,7-10H2,1H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2829-34 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.090 BindingDB Entry DOI: 10.7270/Q2HX1CQX |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50294271
(5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-...)Show InChI InChI=1S/C18H20Cl2N2O/c1-12-5-6-14(11-22-12)18(13-7-9-21-10-8-13)23-16-4-2-3-15(19)17(16)20/h2-6,11,13,18,21H,7-10H2,1H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2829-34 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.090 BindingDB Entry DOI: 10.7270/Q2HX1CQX |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50294271
(5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-...)Show InChI InChI=1S/C18H20Cl2N2O/c1-12-5-6-14(11-22-12)18(13-7-9-21-10-8-13)23-16-4-2-3-15(19)17(16)20/h2-6,11,13,18,21H,7-10H2,1H3 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of CYP2D6 |
Bioorg Med Chem Lett 19: 2829-34 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.090 BindingDB Entry DOI: 10.7270/Q2HX1CQX |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50294271
(5-((2,3-dichlorophenoxy)(piperidin-4-yl)methyl)-2-...)Show InChI InChI=1S/C18H20Cl2N2O/c1-12-5-6-14(11-22-12)18(13-7-9-21-10-8-13)23-16-4-2-3-15(19)17(16)20/h2-6,11,13,18,21H,7-10H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells |
Bioorg Med Chem Lett 19: 2829-34 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.090 BindingDB Entry DOI: 10.7270/Q2HX1CQX |
More data for this Ligand-Target Pair | |