BindingDB PrimarySearch

BDBM50294451 CHEMBL565061::ethyl 7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate::pyrazolo[1,5-a]pyrimidine-3-carboxylate

SMILES: CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1

InChI Key: InChIKey=YCAVTOUTYRMOGQ-UHFFFAOYSA-N

Data: 15 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50294451
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylation				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human recombinant B-Raf expressed in Sf9 cells				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of mTOR				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Tpl2				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of BTK				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of AKT				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of CDK4				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of LCK				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of LYN				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of IGFR1				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of SRC				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylation				Bioorg Med Chem Lett 19: 6571-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.030 BindingDB Entry DOI: 10.7270/Q29Z9510
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Homo sapiens (Human))	BDBM50294451 (CHEMBL565061 \| ethyl 7-(3-(3-(trifluoromethyl)benz...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of PDK1				Bioorg Med Chem Lett 19: 2735-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.129 BindingDB Entry DOI: 10.7270/Q28C9W8N
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair