BindingDB PrimarySearch

BDBM50294542 1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-phenethyl-5,6,7,12-tetrahydro-2,5,12-triaza-dibenzo[a,e]azulene::CHEMBL551570

SMILES: COc1nc(C)cc2N(CCc3ccccc3)CCc3c([nH]c4cc(ccc34)N3CCN(C)CC3)-c12

InChI Key: InChIKey=AAWMAJBBHSVQCG-UHFFFAOYSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50294542
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Insulin receptor (Homo sapiens (Human))	BDBM50294542 (1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
St Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of human recombinant IRK				Bioorg Med Chem 17: 3308-16 (2009) Article DOI: 10.1016/j.bmc.2009.03.046 BindingDB Entry DOI: 10.7270/Q2GX4BKJ
St Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50294542 (1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
St Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of 6xHis-tagged human NPM-ALK expressed in insect cells				Bioorg Med Chem 17: 3308-16 (2009) Article DOI: 10.1016/j.bmc.2009.03.046 BindingDB Entry DOI: 10.7270/Q2GX4BKJ
St Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50294542 (1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
St Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of recombinant MET				Bioorg Med Chem 17: 3308-16 (2009) Article DOI: 10.1016/j.bmc.2009.03.046 BindingDB Entry DOI: 10.7270/Q2GX4BKJ
St Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50294542 (1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
St Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of recombinant JAK2				Bioorg Med Chem 17: 3308-16 (2009) Article DOI: 10.1016/j.bmc.2009.03.046 BindingDB Entry DOI: 10.7270/Q2GX4BKJ
St Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50294542 (1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
St Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of recombinant IGFR1				Bioorg Med Chem 17: 3308-16 (2009) Article DOI: 10.1016/j.bmc.2009.03.046 BindingDB Entry DOI: 10.7270/Q2GX4BKJ
St Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair