BDBM50295196 3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]quinazolin-5(4H)-one::CHEMBL552459

SMILES: CN1CCN(CC1)C(=O)c1cnn2c1[nH]c(=O)c1ccccc21

InChI Key: InChIKey=OWJXFHJPHHEPNZ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50295196   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50295196 (3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]qu...) Show SMILES CN1CCN(CC1)C(=O)c1cnn2c1[nH]c(=O)c1ccccc21 Show InChI InChI=1S/C16H17N5O2/c1-19-6-8-20(9-7-19)16(23)12-10-17-21-13-5-3-2-4-11(13)15(22)18-14(12)21/h2-5,10H,6-9H2,1H3,(H,18,22)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
IRBM - Merck Research Laboratories Rome Curated by ChEMBL					Assay Description Inhibition of PARP1 by scintillation proximity assay				Bioorg Med Chem Lett 19: 4196-200 (2009) Article DOI: 10.1016/j.bmcl.2009.05.113 BindingDB Entry DOI: 10.7270/Q2MG7PHP
					More data for this Ligand-Target Pair