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BDBM50295450 CHEMBL3084657::exo-8-[Bis(2-chlorophenyl)methyl]-3-(5-oxazolyl)-8-azabicyclo-[3.2.1]octane

SMILES: [H][C@]12CC[C@]([H])(C[C@@H](C1)c1cnco1)N2C(c1ccccc1Cl)c1ccccc1Cl

InChI Key: InChIKey=JOBGGLJPDFQHDJ-IRXDYDNUSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50295450   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nociceptin receptor


(Homo sapiens (Human))		BDBM50295450
PNG
(CHEMBL3084657 | exo-8-[Bis(2-chlorophenyl)methyl]-...)
Show SMILES [H][C@]12CC[C@]([H])(C[C@@H](C1)c1cnco1)N2C(c1ccccc1Cl)c1ccccc1Cl |r,TLB:9:7:14:2.3|
Show InChI InChI=1S/C23H22Cl2N2O/c24-20-7-3-1-5-18(20)23(19-6-2-4-8-21(19)25)27-16-9-10-17(27)12-15(11-16)22-13-26-14-28-22/h1-8,13-17,23H,9-12H2/t16-,17-/m0/s1
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 272n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr14-N/OFQ from human NOP receptor expressed in CHO cells by Topcount microplate scintillation counting

J Med Chem 52: 5323-9 (2009)


Article DOI: 10.1021/jm9008218
BindingDB Entry DOI: 10.7270/Q2DV1JX2
More data for this
Ligand-Target Pair