BDBM50295817 12,13-[2-carboxy-cis-2,3-dihydroxy-1,4-butyl]-6,7,12,13-tetrahyhydro-5,7-dioxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole::CHEMBL550791

SMILES: O[C@@H]1Cn2c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n(C[C@@]1(O)C(O)=O)c4c23

InChI Key: InChIKey=HBMVUALJSJNKQX-BZQUYTCOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50295817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50295817 (12,13-[2-carboxy-cis-2,3-dihydroxy-1,4-butyl]-6,7,...) Show SMILES O[C@@H]1Cn2c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n(C[C@@]1(O)C(O)=O)c4c23 |r| Show InChI InChI=1S/C25H17N3O6/c29-15-9-27-13-7-3-1-5-11(13)16-18-19(23(31)26-22(18)30)17-12-6-2-4-8-14(12)28(21(17)20(16)27)10-25(15,34)24(32)33/h1-8,15,29,34H,9-10H2,(H,32,33)(H,26,30,31)/t15-,25+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202 Curated by ChEMBL					Assay Description Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylation				Bioorg Med Chem Lett 19: 3333-8 (2009) Article DOI: 10.1016/j.bmcl.2009.04.039 BindingDB Entry DOI: 10.7270/Q2ZK5GQ8
					More data for this Ligand-Target Pair