BDBM50295903 3-(5-Bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione::CHEMBL561066

SMILES: Brc1ccc2n(CCCn3ccnc3)cc(C3=C(C(=O)NC3=O)n3ccc4ncccc34)c2c1

InChI Key: InChIKey=WAHJVVBFOFEHSE-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50295903   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C epsilon type (Homo sapiens (Human))	BDBM50295903 (3-(5-Bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol...) Show SMILES Brc1ccc2n(CCCn3ccnc3)cc(C3=C(C(=O)NC3=O)n3ccc4ncccc34)c2c1 |t:17| Show InChI InChI=1S/C25H19BrN6O2/c26-16-4-5-20-17(13-16)18(14-31(20)10-2-9-30-12-8-27-15-30)22-23(25(34)29-24(22)33)32-11-6-19-21(32)3-1-7-28-19/h1,3-8,11-15H,2,9-10H2,(H,29,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of recombinant PKCE expressed in Bac-to Bac baculovirus system				Bioorg Med Chem 17: 4302-12 (2009) Article DOI: 10.1016/j.bmc.2009.05.031 BindingDB Entry DOI: 10.7270/Q2XP750M
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM50295903 (3-(5-Bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol...) Show SMILES Brc1ccc2n(CCCn3ccnc3)cc(C3=C(C(=O)NC3=O)n3ccc4ncccc34)c2c1 |t:17| Show InChI InChI=1S/C25H19BrN6O2/c26-16-4-5-20-17(13-16)18(14-31(20)10-2-9-30-12-8-27-15-30)22-23(25(34)29-24(22)33)32-11-6-19-21(32)3-1-7-28-19/h1,3-8,11-15H,2,9-10H2,(H,29,33,34)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of recombinant IKK2 expressed in Bac-to Bac baculovirus system				Bioorg Med Chem 17: 4302-12 (2009) Article DOI: 10.1016/j.bmc.2009.05.031 BindingDB Entry DOI: 10.7270/Q2XP750M
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50295903 (3-(5-Bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol...) Show SMILES Brc1ccc2n(CCCn3ccnc3)cc(C3=C(C(=O)NC3=O)n3ccc4ncccc34)c2c1 |t:17| Show InChI InChI=1S/C25H19BrN6O2/c26-16-4-5-20-17(13-16)18(14-31(20)10-2-9-30-12-8-27-15-30)22-23(25(34)29-24(22)33)32-11-6-19-21(32)3-1-7-28-19/h1,3-8,11-15H,2,9-10H2,(H,29,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of recombinant GST-GSK3beta expressed in Escherichia coli BL21 (DE3)				Bioorg Med Chem 17: 4302-12 (2009) Article DOI: 10.1016/j.bmc.2009.05.031 BindingDB Entry DOI: 10.7270/Q2XP750M
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50295903 (3-(5-Bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol...) Show SMILES Brc1ccc2n(CCCn3ccnc3)cc(C3=C(C(=O)NC3=O)n3ccc4ncccc34)c2c1 |t:17| Show InChI InChI=1S/C25H19BrN6O2/c26-16-4-5-20-17(13-16)18(14-31(20)10-2-9-30-12-8-27-15-30)22-23(25(34)29-24(22)33)32-11-6-19-21(32)3-1-7-28-19/h1,3-8,11-15H,2,9-10H2,(H,29,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of recombinant MEK1 expressed in Escherichia coli				Bioorg Med Chem 17: 4302-12 (2009) Article DOI: 10.1016/j.bmc.2009.05.031 BindingDB Entry DOI: 10.7270/Q2XP750M
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 3 (Homo sapiens (Human))	BDBM50295903 (3-(5-Bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol...) Show SMILES Brc1ccc2n(CCCn3ccnc3)cc(C3=C(C(=O)NC3=O)n3ccc4ncccc34)c2c1 |t:17| Show InChI InChI=1S/C25H19BrN6O2/c26-16-4-5-20-17(13-16)18(14-31(20)10-2-9-30-12-8-27-15-30)22-23(25(34)29-24(22)33)32-11-6-19-21(32)3-1-7-28-19/h1,3-8,11-15H,2,9-10H2,(H,29,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of recombinant ERK1 expressed in Escherichia coli				Bioorg Med Chem 17: 4302-12 (2009) Article DOI: 10.1016/j.bmc.2009.05.031 BindingDB Entry DOI: 10.7270/Q2XP750M
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50295903 (3-(5-Bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol...) Show SMILES Brc1ccc2n(CCCn3ccnc3)cc(C3=C(C(=O)NC3=O)n3ccc4ncccc34)c2c1 |t:17| Show InChI InChI=1S/C25H19BrN6O2/c26-16-4-5-20-17(13-16)18(14-31(20)10-2-9-30-12-8-27-15-30)22-23(25(34)29-24(22)33)32-11-6-19-21(32)3-1-7-28-19/h1,3-8,11-15H,2,9-10H2,(H,29,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of recombinant Aurora A expressed in Escherichia coli				Bioorg Med Chem 17: 4302-12 (2009) Article DOI: 10.1016/j.bmc.2009.05.031 BindingDB Entry DOI: 10.7270/Q2XP750M
					More data for this Ligand-Target Pair