null
SMILES: OC(=O)Cc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc2ccccc2c1
InChI Key: InChIKey=SWXKLXXVFMYMDP-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human)) | BDBM50296004 (2-(4-(5-(naphthalen-2-yl)-1H-pyrrolo[2,3-b]pyridin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of SGK1-mediated epithelial sodium channel activity in human M-1 cells assessed as short circuit current by whole cell electrophysiologica... | Bioorg Med Chem Lett 19: 4441-5 (2009) Article DOI: 10.1016/j.bmcl.2009.05.051 BindingDB Entry DOI: 10.7270/Q2WQ03VC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human)) | BDBM50296004 (2-(4-(5-(naphthalen-2-yl)-1H-pyrrolo[2,3-b]pyridin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of SGK1 by fluorescence polarization assay | Bioorg Med Chem Lett 19: 4441-5 (2009) Article DOI: 10.1016/j.bmcl.2009.05.051 BindingDB Entry DOI: 10.7270/Q2WQ03VC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |