null

SMILES: CN1CCN(CC1)C1CC(C1)c1c(ccc2ccc(nc12)-c1ccccc1)-c1ncn2ccnc(N)c12

InChI Key: InChIKey=LHXVJSAPHKTYCV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50296352   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50296352 (1-(8-(3-(4-methylpiperazin-1-yl)cyclobutyl)-2-phen...) Show SMILES CN1CCN(CC1)C1CC(C1)c1c(ccc2ccc(nc12)-c1ccccc1)-c1ncn2ccnc(N)c12 |(21.77,-8.21,;20.98,-6.88,;19.44,-6.89,;18.66,-5.58,;19.42,-4.23,;20.96,-4.21,;21.74,-5.54,;18.63,-2.91,;17.14,-2.53,;17.52,-1.04,;19.01,-1.42,;16.74,.28,;15.2,.27,;14.4,1.57,;15.14,2.92,;16.69,2.95,;17.44,4.3,;18.98,4.33,;19.78,2.99,;19.03,1.64,;17.48,1.62,;21.32,3.02,;22.11,1.69,;23.65,1.72,;24.4,3.06,;23.6,4.39,;22.06,4.36,;14.45,-1.08,;15.1,-2.47,;13.98,-3.52,;12.64,-2.77,;11.19,-3.27,;10.03,-2.27,;10.32,-.76,;11.78,-.25,;12.07,1.26,;12.93,-1.27,)| Show InChI InChI=1S/C30H31N7/c1-35-13-15-36(16-14-35)23-17-22(18-23)26-24(28-29-30(31)32-11-12-37(29)19-33-28)9-7-21-8-10-25(34-27(21)26)20-5-3-2-4-6-20/h2-12,19,22-23H,13-18H2,1H3,(H2,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Inhibition of IGF1R by cell based assay				J Med Chem 52: 4981-5004 (2010) Article DOI: 10.1021/jm9002395 BindingDB Entry DOI: 10.7270/Q2P84CTD
					More data for this Ligand-Target Pair