BDBM50296453 5-((1H-indol-3-yl)methylene)-2-(3,5-dichlorophenylamino)thiazol-4(5H)-one::CHEMBL557113

SMILES: Clc1cc(Cl)cc(NC2=NC(=O)C(S2)=Cc2c[nH]c3ccccc23)c1

InChI Key: InChIKey=YPGKAUICNLTEKA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50296453   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity phosphatase Cdc25B (Homo sapiens (Human))	BDBM50296453 (5-((1H-indol-3-yl)methylene)-2-(3,5-dichlorophenyl...) Show SMILES Clc1cc(Cl)cc(NC2=NC(=O)C(S2)=Cc2c[nH]c3ccccc23)c1 |w:14.15,t:8| Show InChI InChI=1S/C18H11Cl2N3OS/c19-11-6-12(20)8-13(7-11)22-18-23-17(24)16(25-18)5-10-9-21-15-4-2-1-3-14(10)15/h1-9,21H,(H,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sejong University Curated by ChEMBL					Assay Description Inhibition of N-terminal 6xHis-tagged (378-566) catalytic domain of Cdc25B expressed in Escherichia coli after 20 mins by by fluorescent plate reader...				Bioorg Med Chem Lett 19: 4330-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.084 BindingDB Entry DOI: 10.7270/Q2NZ87P2
					More data for this Ligand-Target Pair
phosphatase Cdc25 (Homo sapiens (Human))	BDBM50296453 (5-((1H-indol-3-yl)methylene)-2-(3,5-dichlorophenyl...) Show SMILES Clc1cc(Cl)cc(NC2=NC(=O)C(S2)=Cc2c[nH]c3ccccc23)c1 |w:14.15,t:8| Show InChI InChI=1S/C18H11Cl2N3OS/c19-11-6-12(20)8-13(7-11)22-18-23-17(24)16(25-18)5-10-9-21-15-4-2-1-3-14(10)15/h1-9,21H,(H,22,23,24)	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.27E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sejong University Curated by ChEMBL					Assay Description Inhibition of N-terminal 6xHis-tagged human Cdc25A (336-523) catalytic domain expressed in Escherichia coli after 20 mins by fluorescent plate reader...				Bioorg Med Chem Lett 19: 4330-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.084 BindingDB Entry DOI: 10.7270/Q2NZ87P2
					More data for this Ligand-Target Pair