null

SMILES: CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(C)n1-c1cc(F)cc(F)c1

InChI Key: InChIKey=WXGFDISGDAGZCW-CJNGLKHVSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296915   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50296915 ((1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-m...) Show SMILES CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(C)n1-c1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C19H24F3N3/c1-11(2)19-18(10-23-16-5-4-13(20)7-16)24-12(3)25(19)17-8-14(21)6-15(22)9-17/h6,8-9,11,13,16,23H,4-5,7,10H2,1-3H3/t13-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50296915 ((1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-m...) Show SMILES CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(C)n1-c1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C19H24F3N3/c1-11(2)19-18(10-23-16-5-4-13(20)7-16)24-12(3)25(19)17-8-14(21)6-15(22)9-17/h6,8-9,11,13,16,23H,4-5,7,10H2,1-3H3/t13-,16+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [35S]MK499 from human ERG expressed in HEK293 cells overexpressing Ikr channel protein				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296915 ((1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-m...) Show SMILES CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(C)n1-c1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C19H24F3N3/c1-11(2)19-18(10-23-16-5-4-13(20)7-16)24-12(3)25(19)17-8-14(21)6-15(22)9-17/h6,8-9,11,13,16,23H,4-5,7,10H2,1-3H3/t13-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair