BDBM50297421 CHEMBL558525::N-methyl-1-((1R,2R)-2-(naphthalen-1-yloxy)-2-(thiophen-2-yl)cyclopropyl)methanamine hydrochloride
SMILES: CNC[C@H]1C[C@]1(Oc1cccc2ccccc12)c1cccs1
InChI Key: InChIKey=YFHROOMCIQOYDA-DNVCBOLYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50297421 (CHEMBL558525 | N-methyl-1-((1R,2R)-2-(naphthalen-1...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 27.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Oregon State University Curated by ChEMBL | Assay Description Inhibition of [3H]norepinephrine reuptake at norepinephrine transporter | J Med Chem 52: 5872-9 (2009) Article DOI: 10.1021/jm900847b BindingDB Entry DOI: 10.7270/Q26Q1XBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50297421 (CHEMBL558525 | N-methyl-1-((1R,2R)-2-(naphthalen-1...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 30.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Oregon State University Curated by ChEMBL | Assay Description Inhibition of [3H]serotonin reuptake at serotonin transporter | J Med Chem 52: 5872-9 (2009) Article DOI: 10.1021/jm900847b BindingDB Entry DOI: 10.7270/Q26Q1XBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50297421 (CHEMBL558525 | N-methyl-1-((1R,2R)-2-(naphthalen-1...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Oregon State University Curated by ChEMBL | Assay Description Inhibition of [3H]dopamine reuptake at dopamine transporter | J Med Chem 52: 5872-9 (2009) Article DOI: 10.1021/jm900847b BindingDB Entry DOI: 10.7270/Q26Q1XBR | |||||||||||
More data for this Ligand-Target Pair |