BDBM50297860 1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-yl)-N-methyl-N-((tetrahydro-2H-pyran-4-yl)methyl)piperidin-4-amine::CHEMBL558663

SMILES: COc1ccc(Cn2c(nc3ccccc23)N2CCC(CC2)N(C)CC2CCOCC2)cc1

InChI Key: InChIKey=TVKCCIBAUDHHBL-UHFFFAOYSA-N

Data: 2 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50297860   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H1 receptor (Homo sapiens (Human))	BDBM50297860 (1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-yl)-N...) Show SMILES COc1ccc(Cn2c(nc3ccccc23)N2CCC(CC2)N(C)CC2CCOCC2)cc1 Show InChI InChI=1S/C27H36N4O2/c1-29(19-22-13-17-33-18-14-22)23-11-15-30(16-12-23)27-28-25-5-3-4-6-26(25)31(27)20-21-7-9-24(32-2)10-8-21/h3-10,22-23H,11-20H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay				Bioorg Med Chem Lett 19: 4380-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.086 BindingDB Entry DOI: 10.7270/Q2KS6RM8
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50297860 (1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-yl)-N...) Show SMILES COc1ccc(Cn2c(nc3ccccc23)N2CCC(CC2)N(C)CC2CCOCC2)cc1 Show InChI InChI=1S/C27H36N4O2/c1-29(19-22-13-17-33-18-14-22)23-11-15-30(16-12-23)27-28-25-5-3-4-6-26(25)31(27)20-21-7-9-24(32-2)10-8-21/h3-10,22-23H,11-20H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	102	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells at 37 degC by liquid scintillation assay				Bioorg Med Chem Lett 19: 4380-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.086 BindingDB Entry DOI: 10.7270/Q2KS6RM8
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50297860 (1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-yl)-N...) Show SMILES COc1ccc(Cn2c(nc3ccccc23)N2CCC(CC2)N(C)CC2CCOCC2)cc1 Show InChI InChI=1S/C27H36N4O2/c1-29(19-22-13-17-33-18-14-22)23-11-15-30(16-12-23)27-28-25-5-3-4-6-26(25)31(27)20-21-7-9-24(32-2)10-8-21/h3-10,22-23H,11-20H2,1-2H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Inhibition of CYP2D6				Bioorg Med Chem Lett 19: 4380-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.086 BindingDB Entry DOI: 10.7270/Q2KS6RM8
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50297860 (1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-yl)-N...) Show SMILES COc1ccc(Cn2c(nc3ccccc23)N2CCC(CC2)N(C)CC2CCOCC2)cc1 Show InChI InChI=1S/C27H36N4O2/c1-29(19-22-13-17-33-18-14-22)23-11-15-30(16-12-23)27-28-25-5-3-4-6-26(25)31(27)20-21-7-9-24(32-2)10-8-21/h3-10,22-23H,11-20H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Inhibition of CYP3A4				Bioorg Med Chem Lett 19: 4380-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.086 BindingDB Entry DOI: 10.7270/Q2KS6RM8
					More data for this Ligand-Target Pair