BDBM50297872 CHEMBL561489::N-(1-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidin-4-yl)-N-methylpyrimidin-2-amine

SMILES: CN(C1CCN(CC1)c1nc2ccccc2n1Cc1ccc(F)cc1)c1ncccn1

InChI Key: InChIKey=HEFAAVYYGFTJLY-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50297872   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H1 receptor (Homo sapiens (Human))	BDBM50297872 (CHEMBL561489 | N-(1-(1-(4-fluorobenzyl)-1H-benzo[d...) Show SMILES CN(C1CCN(CC1)c1nc2ccccc2n1Cc1ccc(F)cc1)c1ncccn1 Show InChI InChI=1S/C24H25FN6/c1-29(23-26-13-4-14-27-23)20-11-15-30(16-12-20)24-28-21-5-2-3-6-22(21)31(24)17-18-7-9-19(25)10-8-18/h2-10,13-14,20H,11-12,15-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	75.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assay				Bioorg Med Chem Lett 19: 4380-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.086 BindingDB Entry DOI: 10.7270/Q2KS6RM8
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50297872 (CHEMBL561489 | N-(1-(1-(4-fluorobenzyl)-1H-benzo[d...) Show SMILES CN(C1CCN(CC1)c1nc2ccccc2n1Cc1ccc(F)cc1)c1ncccn1 Show InChI InChI=1S/C24H25FN6/c1-29(23-26-13-4-14-27-23)20-11-15-30(16-12-20)24-28-21-5-2-3-6-22(21)31(24)17-18-7-9-19(25)10-8-18/h2-10,13-14,20H,11-12,15-17H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Inhibition of CYP2D6				Bioorg Med Chem Lett 19: 4380-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.086 BindingDB Entry DOI: 10.7270/Q2KS6RM8
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50297872 (CHEMBL561489 | N-(1-(1-(4-fluorobenzyl)-1H-benzo[d...) Show SMILES CN(C1CCN(CC1)c1nc2ccccc2n1Cc1ccc(F)cc1)c1ncccn1 Show InChI InChI=1S/C24H25FN6/c1-29(23-26-13-4-14-27-23)20-11-15-30(16-12-20)24-28-21-5-2-3-6-22(21)31(24)17-18-7-9-19(25)10-8-18/h2-10,13-14,20H,11-12,15-17H2,1H3	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Displacement of [3H]N-methyl scopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells by liquid scintillation assay				Bioorg Med Chem Lett 19: 4380-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.086 BindingDB Entry DOI: 10.7270/Q2KS6RM8
					More data for this Ligand-Target Pair