null

SMILES: C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCC(O)C2)cc1Cl

InChI Key: InChIKey=KSZQDCYDVPKHGA-LDCVWXEPSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50297980   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50297980 (3-((1R)-1-(2-chloro-4-((3-hydroxypyrrolidin-1-yl)m...) Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCC(O)C2)cc1Cl |r| Show InChI InChI=1S/C25H25ClN4O3S/c1-15(18-6-5-16(10-19(18)26)13-29-9-7-17(31)14-29)33-21-11-22(34-24(21)25(27)32)20-12-28-23-4-2-3-8-30(20)23/h2-6,8,10-12,15,17,31H,7,9,13-14H2,1H3,(H2,27,32)/t15-,17?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of PLK1				Bioorg Med Chem Lett 19: 4673-8 (2009) Article DOI: 10.1016/j.bmcl.2009.06.084 BindingDB Entry DOI: 10.7270/Q22R3RQG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50297980 (3-((1R)-1-(2-chloro-4-((3-hydroxypyrrolidin-1-yl)m...) Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCC(O)C2)cc1Cl |r| Show InChI InChI=1S/C25H25ClN4O3S/c1-15(18-6-5-16(10-19(18)26)13-29-9-7-17(31)14-29)33-21-11-22(34-24(21)25(27)32)20-12-28-23-4-2-3-8-30(20)23/h2-6,8,10-12,15,17,31H,7,9,13-14H2,1H3,(H2,27,32)/t15-,17?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.27E+5	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of PLK1-mediated mitosis in human HeLaS3 cells after 18 hrs				Bioorg Med Chem Lett 19: 4673-8 (2009) Article DOI: 10.1016/j.bmcl.2009.06.084 BindingDB Entry DOI: 10.7270/Q22R3RQG
					More data for this Ligand-Target Pair