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SMILES: CN(CCNC(=O)CCCC(=O)NCCN(C)CCn1nc2-c3cccc(Cl)c3C(=O)c3cccc1c23)CCn1nc2-c3cccc(Cl)c3C(=O)c3cccc1c23

InChI Key: InChIKey=YZRINCXVZSNLME-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50298273   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha


(Homo sapiens (Human))		BDBM50298273
PNG
(CHEMBL575641 | N,N'-Bis(2-((2-(7-chloro-6-oxo-6H-d...)
Show SMILES CN(CCNC(=O)CCCC(=O)NCCN(C)CCn1nc2-c3cccc(Cl)c3C(=O)c3cccc1c23)CCn1nc2-c3cccc(Cl)c3C(=O)c3cccc1c23
Show InChI InChI=1S/C43H42Cl2N8O4/c1-50(22-24-52-32-14-5-10-28-38(32)40(48-52)26-8-3-12-30(44)36(26)42(28)56)20-18-46-34(54)16-7-17-35(55)47-19-21-51(2)23-25-53-33-15-6-11-29-39(33)41(49-53)27-9-4-13-31(45)37(27)43(29)57/h3-6,8-15H,7,16-25H2,1-2H3,(H,46,54)(H,47,55)
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Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



University of Manitoba

Curated by ChEMBL


Assay Description
Inhibition of decatenation activity of human topoisomerase 2alpha

Bioorg Med Chem 17: 4575-82 (2009)


Article DOI: 10.1016/j.bmc.2009.04.072
BindingDB Entry DOI: 10.7270/Q28915XR
More data for this
Ligand-Target Pair