BDBM50298280 CHEMBL574266::N-(4-Amino-2,6-diisopropylphenyl)-N'-{[4-(3-hydroxyphenyl)-1-(2-methoxyphenyl)piperidin-4-yl]methyl}-urea dihydrochloride

SMILES: COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(O)c1

InChI Key: InChIKey=DXJCJLIREABZOD-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50298280   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sterol O-acyltransferase, Soat (Rattus norvegicus)	BDBM50298280 (CHEMBL574266 | N-(4-Amino-2,6-diisopropylphenyl)-N...) Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(O)c1 Show InChI InChI=1S/C32H42N4O3/c1-21(2)26-18-24(33)19-27(22(3)4)30(26)35-31(38)34-20-32(23-9-8-10-25(37)17-23)13-15-36(16-14-32)28-11-6-7-12-29(28)39-5/h6-12,17-19,21-22,37H,13-16,20,33H2,1-5H3,(H2,34,35,38)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	797	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...				Bioorg Med Chem 17: 4636-46 (2009) Article DOI: 10.1016/j.bmc.2009.04.059 BindingDB Entry DOI: 10.7270/Q24M94KR
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