BDBM50298309 CHEMBL574533::ETP-7146::N-(3-methoxyphenyl)-1-methyl-6-(4-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

SMILES: COc1cccc(Nc2nc(nc3n(C)ncc23)N2CCN(C)CC2)c1

InChI Key: InChIKey=OCGQAKYJZXVEPH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50298309   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50298309 (CHEMBL574533 | ETP-7146 | N-(3-methoxyphenyl)-1-me...) Show SMILES COc1cccc(Nc2nc(nc3n(C)ncc23)N2CCN(C)CC2)c1 Show InChI InChI=1S/C18H23N7O/c1-23-7-9-25(10-8-23)18-21-16(15-12-19-24(2)17(15)22-18)20-13-5-4-6-14(11-13)26-3/h4-6,11-12H,7-10H2,1-3H3,(H,20,21,22)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Science and Technology Curated by ChEMBL					Assay Description Displacement of [3H]Mesulergine from human recombinant serotonin 5-HT2C expressed in CHO-K1 cells				Bioorg Med Chem 17: 4559-68 (2009) Article DOI: 10.1016/j.bmc.2009.05.003 BindingDB Entry DOI: 10.7270/Q20V8CV1
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50298309 (CHEMBL574533 | ETP-7146 | N-(3-methoxyphenyl)-1-me...) Show SMILES COc1cccc(Nc2nc(nc3n(C)ncc23)N2CCN(C)CC2)c1 Show InChI InChI=1S/C18H23N7O/c1-23-7-9-25(10-8-23)18-21-16(15-12-19-24(2)17(15)22-18)20-13-5-4-6-14(11-13)26-3/h4-6,11-12H,7-10H2,1-3H3,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Spanish National Cancer Research Center (CNIO)					Assay Description Kinase assay using PI3K.				J Biol Chem 284: 28392-400 (2009) Article DOI: 10.1074/jbc.M109.038984 BindingDB Entry DOI: 10.7270/Q2N01556
					More data for this Ligand-Target Pair