BDBM50299233 1-Benzyl-7-p-fluorophenyl-8-(2-methoxyphenyl)-1H-imidazo-[2,1-f]purine-2,4(3H,8H)-dione::CHEMBL586052

SMILES: COc1ccccc1-n1c(cn2c1nc1n(Cc3ccccc3)c(=O)[nH]c(=O)c21)-c1ccc(F)cc1

InChI Key: InChIKey=YAGDBLVGQCHWPO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50299233   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50299233 (1-Benzyl-7-p-fluorophenyl-8-(2-methoxyphenyl)-1H-i...) Show SMILES COc1ccccc1-n1c(cn2c1nc1n(Cc3ccccc3)c(=O)[nH]c(=O)c21)-c1ccc(F)cc1 |(.93,-16.47,;.93,-14.93,;2.27,-14.16,;3.59,-14.93,;4.92,-14.16,;4.92,-12.62,;3.59,-11.86,;2.27,-12.62,;.94,-11.86,;.95,-10.31,;-.52,-9.83,;-1.43,-11.07,;-.53,-12.33,;-1.43,-13.57,;-2.9,-13.09,;-4.22,-13.85,;-4.23,-15.39,;-5.56,-16.16,;-6.88,-15.39,;-8.22,-16.16,;-8.22,-17.7,;-6.88,-18.47,;-5.55,-17.69,;-5.55,-13.09,;-6.89,-13.86,;-5.55,-11.55,;-4.22,-10.77,;-4.22,-9.23,;-2.9,-11.55,;2.28,-9.54,;3.62,-10.3,;4.94,-9.53,;4.94,-7.98,;6.26,-7.21,;3.59,-7.22,;2.27,-8,)| Show InChI InChI=1S/C27H20FN5O3/c1-36-22-10-6-5-9-20(22)33-21(18-11-13-19(28)14-12-18)16-31-23-24(29-26(31)33)32(27(35)30-25(23)34)15-17-7-3-2-4-8-17/h2-14,16H,15H2,1H3,(H,30,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay				J Med Chem 52: 6433-46 (2009) Article DOI: 10.1021/jm9009444 BindingDB Entry DOI: 10.7270/Q2BZ663G
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