null

SMILES: CNC(=O)Nc1ccc(cc1)-c1nc(N2C3CCC2COC3)c2cnn(CC(F)(F)F)c2n1

InChI Key: InChIKey=YKHJGTINLIVMSH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50300076   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50300076 (1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1-(2...) Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2C3CCC2COC3)c2cnn(CC(F)(F)F)c2n1 Show InChI InChI=1S/C21H22F3N7O2/c1-25-20(32)27-13-4-2-12(3-5-13)17-28-18-16(8-26-30(18)11-21(22,23)24)19(29-17)31-14-6-7-15(31)10-33-9-14/h2-5,8,14-15H,6-7,9-11H2,1H3,(H2,25,27,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha				J Med Chem 52: 7942-5 (2009) Article DOI: 10.1021/jm901415x BindingDB Entry DOI: 10.7270/Q2WM1DGH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50300076 (1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1-(2...) Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2C3CCC2COC3)c2cnn(CC(F)(F)F)c2n1 Show InChI InChI=1S/C21H22F3N7O2/c1-25-20(32)27-13-4-2-12(3-5-13)17-28-18-16(8-26-30(18)11-21(22,23)24)19(29-17)31-14-6-7-15(31)10-33-9-14/h2-5,8,14-15H,6-7,9-11H2,1H3,(H2,25,27,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Flag-tagged human mTOR by DELFIA method				J Med Chem 52: 7942-5 (2009) Article DOI: 10.1021/jm901415x BindingDB Entry DOI: 10.7270/Q2WM1DGH
					More data for this Ligand-Target Pair