BDBM50300300 4-Amino-N'-hydroxy-N-(3-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide::CHEMBL565489
SMILES: Cc1cccc(c1)N=C(NO)c1nonc1N
InChI Key: InChIKey=AWLNUYVOVDYODL-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM50300300 (4-Amino-N'-hydroxy-N-(3-methylphenyl)-1,2,5-oxadia...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation Curated by ChEMBL | Assay Description Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometry | J Med Chem 52: 7364-7 (2009) Article DOI: 10.1021/jm900518f BindingDB Entry DOI: 10.7270/Q29P32KW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM50300300 (4-Amino-N'-hydroxy-N-(3-methylphenyl)-1,2,5-oxadia...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation Curated by ChEMBL | Assay Description Inhibition of N-terminal his-tagged human indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as N'-formylkynurenine formation by spec... | J Med Chem 52: 7364-7 (2009) Article DOI: 10.1021/jm900518f BindingDB Entry DOI: 10.7270/Q29P32KW | |||||||||||
More data for this Ligand-Target Pair |