BDBM50300694 CHEMBL575312::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(4-methylpiperazin-1-yl)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

SMILES: CN1CCN(CC1)c1ccc2c(c1)sc1nc(cn21)-c1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1

InChI Key: InChIKey=HNKRMPJIWHKDDU-UHFFFAOYSA-N

Data: 1 Kd

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50300694   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50300694 (CHEMBL575312 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES CN1CCN(CC1)c1ccc2c(c1)sc1nc(cn21)-c1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1 Show InChI InChI=1S/C28H31N7O2S/c1-28(2,3)24-16-25(32-37-24)31-26(36)29-19-7-5-18(6-8-19)21-17-35-22-10-9-20(15-23(22)38-27(35)30-21)34-13-11-33(4)12-14-34/h5-10,15-17H,11-14H2,1-4H3,(H2,29,31,32,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay				J Med Chem 52: 7808-16 (2009) Article DOI: 10.1021/jm9007533 BindingDB Entry DOI: 10.7270/Q2319VZ6
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