BDBM50300705 CHEMBL574526::N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(3-morpholino-4-yl-3-oxopropyl)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(CCC(=O)N4CCOCC4)ccc32)no1

InChI Key: InChIKey=YARPTJZYFILFOJ-UHFFFAOYSA-N

Data: 1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50300705   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50300705 (CHEMBL574526 | N-(5-tert-Butylisoxazol-3-yl)-N'-{4...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(CCC(=O)N4CCOCC4)ccc32)no1 Show InChI InChI=1S/C30H32N6O4S/c1-30(2,3)25-17-26(34-40-25)33-28(38)31-21-8-6-20(7-9-21)22-18-36-23-10-4-19(16-24(23)41-29(36)32-22)5-11-27(37)35-12-14-39-15-13-35/h4,6-10,16-18H,5,11-15H2,1-3H3,(H2,31,33,34,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay				J Med Chem 52: 7808-16 (2009) Article DOI: 10.1021/jm9007533 BindingDB Entry DOI: 10.7270/Q2319VZ6
					More data for this Ligand-Target Pair