BDBM50300723 8-(3-tert-butylphenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL583213

SMILES: CC(C)(C)c1cccc(c1)C1(N=C(N)N2CCCN=C12)c1ccccc1

InChI Key: InChIKey=ADMMMBVWAVNVKS-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50300723   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM50300723 (8-(3-tert-butylphenyl)-8-phenyl-2,3,4,8-tetrahydro...) Show SMILES CC(C)(C)c1cccc(c1)C1(N=C(N)N2CCCN=C12)c1ccccc1 |t:12,19| Show InChI InChI=1S/C22H26N4/c1-21(2,3)17-11-7-12-18(15-17)22(16-9-5-4-6-10-16)19-24-13-8-14-26(19)20(23)25-22/h4-7,9-12,15H,8,13-14H2,1-3H3,(H2,23,25)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human BACE1 by FRET				J Med Chem 52: 6314-23 (2009) Article DOI: 10.1021/jm9006752 BindingDB Entry DOI: 10.7270/Q2Z89CHR
					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM50300723 (8-(3-tert-butylphenyl)-8-phenyl-2,3,4,8-tetrahydro...) Show SMILES CC(C)(C)c1cccc(c1)C1(N=C(N)N2CCCN=C12)c1ccccc1 |t:12,19| Show InChI InChI=1S/C22H26N4/c1-21(2,3)17-11-7-12-18(15-17)22(16-9-5-4-6-10-16)19-24-13-8-14-26(19)20(23)25-22/h4-7,9-12,15H,8,13-14H2,1-3H3,(H2,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human cathepsin D by FRET				J Med Chem 52: 6314-23 (2009) Article DOI: 10.1021/jm9006752 BindingDB Entry DOI: 10.7270/Q2Z89CHR
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50300723 (8-(3-tert-butylphenyl)-8-phenyl-2,3,4,8-tetrahydro...) Show SMILES CC(C)(C)c1cccc(c1)C1(N=C(N)N2CCCN=C12)c1ccccc1 |t:12,19| Show InChI InChI=1S/C22H26N4/c1-21(2,3)17-11-7-12-18(15-17)22(16-9-5-4-6-10-16)19-24-13-8-14-26(19)20(23)25-22/h4-7,9-12,15H,8,13-14H2,1-3H3,(H2,23,25)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISA				J Med Chem 52: 6314-23 (2009) Article DOI: 10.1021/jm9006752 BindingDB Entry DOI: 10.7270/Q2Z89CHR
					More data for this Ligand-Target Pair