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SMILES: N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NC(c2ccc3ccccc3c2)C(F)(F)F)n1)C(O)=O

InChI Key: InChIKey=PBPZTYJTIDVGLQ-OYKVQYDMSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50300939   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))		BDBM50300939
PNG
((2S)-2-amino-3-(4-(4-amino-6-(2,2,2-trifluoro-1-(n...)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1nc(N)nc(NC(c2ccc3ccccc3c2)C(F)(F)F)n1)C(O)=O |r|
Show InChI InChI=1S/C24H21F3N6O2/c25-24(26,27)19(17-10-9-14-3-1-2-4-16(14)12-17)30-23-32-20(31-22(29)33-23)15-7-5-13(6-8-15)11-18(28)21(34)35/h1-10,12,18-19H,11,28H2,(H,34,35)(H3,29,30,31,32,33)/t18-,19?/m0/s1
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Princ

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TPH1 by continuous fluorescence assay

Bioorg Med Chem Lett 19: 5229-32 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.005
BindingDB Entry DOI: 10.7270/Q2MS3SV0
More data for this
Ligand-Target Pair