null

SMILES: OCCC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1

InChI Key: InChIKey=FXDKQYLSAJPEQV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50301172   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50301172 (3-hydroxy-N-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-py...) Show SMILES OCCC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(-.41,-10.95,;.91,-10.15,;2.26,-10.9,;3.58,-10.1,;3.55,-8.56,;4.93,-10.85,;6.25,-10.05,;6.22,-8.51,;7.54,-7.72,;8.88,-8.47,;10.2,-7.67,;11.54,-8.42,;11.57,-9.96,;10.25,-10.76,;8.9,-10.01,;7.59,-10.79,;10.17,-6.13,;8.91,-5.25,;7.37,-5.27,;6.87,-3.81,;8.11,-2.89,;9.37,-3.78,;10.91,-3.75,;11.41,-5.21,;12.74,-5.97,;12.75,-7.51,;14.09,-8.28,;15.42,-7.5,;15.4,-5.95,;14.06,-5.19,)| Show InChI InChI=1S/C23H21N5O2/c29-13-9-21(30)26-15-6-7-16-17(8-11-25-19(16)14-15)22-20-5-3-12-28(20)27-23(22)18-4-1-2-10-24-18/h1-2,4,6-8,10-11,14,29H,3,5,9,12-13H2,(H,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of TGFR1				Eur J Med Chem 44: 4259-65 (2009) Article DOI: 10.1016/j.ejmech.2009.07.008 BindingDB Entry DOI: 10.7270/Q2BC3ZM9
					More data for this Ligand-Target Pair