BDBM50301289 1-benzyl-1,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepine::CHEMBL565536

SMILES: C(c1ccccc1)n1ncc2CCNCCc12

InChI Key: InChIKey=ZGIWZGNMDGBKKJ-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50301289   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50301289 (1-benzyl-1,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepi...) Show SMILES C(c1ccccc1)n1ncc2CCNCCc12 Show InChI InChI=1S/C14H17N3/c1-2-4-12(5-3-1)11-17-14-7-9-15-8-6-13(14)10-16-17/h1-5,10,15H,6-9,11H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 19: 4999-5003 (2009) Article DOI: 10.1016/j.bmcl.2009.07.063 BindingDB Entry DOI: 10.7270/Q29C6XHC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50301289 (1-benzyl-1,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepi...) Show SMILES C(c1ccccc1)n1ncc2CCNCCc12 Show InChI InChI=1S/C14H17N3/c1-2-4-12(5-3-1)11-17-14-7-9-15-8-6-13(14)10-16-17/h1-5,10,15H,6-9,11H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 4117-21 (2016) Article DOI: 10.1016/j.bmcl.2016.06.060
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50301289 (1-benzyl-1,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepi...) Show SMILES C(c1ccccc1)n1ncc2CCNCCc12 Show InChI InChI=1S/C14H17N3/c1-2-4-12(5-3-1)11-17-14-7-9-15-8-6-13(14)10-16-17/h1-5,10,15H,6-9,11H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 26: 4117-21 (2016) Article DOI: 10.1016/j.bmcl.2016.06.060
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50301289 (1-benzyl-1,4,5,6,7,8-hexahydropyrazolo[4,3-d]azepi...) Show SMILES C(c1ccccc1)n1ncc2CCNCCc12 Show InChI InChI=1S/C14H17N3/c1-2-4-12(5-3-1)11-17-14-7-9-15-8-6-13(14)10-16-17/h1-5,10,15H,6-9,11H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 19: 4999-5003 (2009) Article DOI: 10.1016/j.bmcl.2009.07.063 BindingDB Entry DOI: 10.7270/Q29C6XHC
					More data for this Ligand-Target Pair