Found 12 hits for monomerid = 50301356 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein-tyrosine kinase 2-beta
(Mus musculus) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in osteocalcin level |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |
PTK2B protein tyrosine kinase 2 beta (PTK2B)
(Homo sapiens (Human)) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human Pyk2 by HTRF assay |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |
Protein-tyrosine kinase 2-beta
(Mus musculus) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in alkaline phosphatase level |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |
Protein-tyrosine kinase 2-beta
(Mus musculus) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in calcium level |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak1 |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |
Focal adhesion kinase 1
(Homo sapiens (Human)) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human FAK by HTRF assay |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak3 |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |
Eukaryotic translation initiation factor 2-alpha kinase 3
(Homo sapiens (Human)) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PEK |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of TYK2 |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |
Interferon-induced, double-stranded RNA-activated protein kinase
(Homo sapiens (Human)) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PKR |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |
PTK2B protein tyrosine kinase 2 beta (PTK2B)
(Homo sapiens (Human)) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human PyK2 Y402 autophosphorylation expressed in 293T cells by immunofluorescence assay |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50301356
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak2 |
Bioorg Med Chem Lett 19: 4924-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2 |
More data for this Ligand-Target Pair | |