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BDBM50301362 4-(2-methoxyethylamino)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide::CHEMBL570955

SMILES: COCCNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)ccc23)cn1

InChI Key: InChIKey=AKLARZWWYXICKZ-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50301362   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50301362
PNG
(4-(2-methoxyethylamino)-N-(5-(7-methoxyquinolin-4-...)
Show SMILES COCCNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)ccc23)cn1
Show InChI InChI=1S/C30H27N5O5/c1-38-17-15-32-24-13-16-35(20-6-4-3-5-7-20)30(37)28(24)29(36)34-27-11-9-22(19-33-27)40-26-12-14-31-25-18-21(39-2)8-10-23(25)26/h3-14,16,18-19,32H,15,17H2,1-2H3,(H,33,34,36)
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Article
PubMed
n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human FAK by HTRF assay


Bioorg Med Chem Lett 19: 4924-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.084
BindingDB Entry DOI: 10.7270/Q2N017G2
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM50301362
PNG
(4-(2-methoxyethylamino)-N-(5-(7-methoxyquinolin-4-...)
Show SMILES COCCNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)ccc23)cn1
Show InChI InChI=1S/C30H27N5O5/c1-38-17-15-32-24-13-16-35(20-6-4-3-5-7-20)30(37)28(24)29(36)34-27-11-9-22(19-33-27)40-26-12-14-31-25-18-21(39-2)8-10-23(25)26/h3-14,16,18-19,32H,15,17H2,1-2H3,(H,33,34,36)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Pyk2 by HTRF assay


Bioorg Med Chem Lett 19: 4924-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.084
BindingDB Entry DOI: 10.7270/Q2N017G2
More data for this
Ligand-Target Pair