BDBM50301367 CHEMBL570381::N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1-phenyl-5-(pyridin-3-yl)-1,2-dihydropyridine-3-carboxamide

SMILES: COc1ccc2c(Oc3ccc(NC(=O)c4cc(cn(-c5ccccc5)c4=O)-c4cccnc4)nc3)ccnc2c1

InChI Key: InChIKey=PPAKRHMKGUVRPM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50301367   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50301367 (CHEMBL570381 | N-(5-(7-methoxyquinolin-4-yloxy)pyr...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4cc(cn(-c5ccccc5)c4=O)-c4cccnc4)nc3)ccnc2c1 Show InChI InChI=1S/C32H23N5O4/c1-40-24-9-11-26-28(17-24)34-15-13-29(26)41-25-10-12-30(35-19-25)36-31(38)27-16-22(21-6-5-14-33-18-21)20-37(32(27)39)23-7-3-2-4-8-23/h2-20H,1H3,(H,35,36,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human FAK by HTRF assay				Bioorg Med Chem Lett 19: 4924-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2
					More data for this Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B) (Homo sapiens (Human))	BDBM50301367 (CHEMBL570381 | N-(5-(7-methoxyquinolin-4-yloxy)pyr...) Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4cc(cn(-c5ccccc5)c4=O)-c4cccnc4)nc3)ccnc2c1 Show InChI InChI=1S/C32H23N5O4/c1-40-24-9-11-26-28(17-24)34-15-13-29(26)41-25-10-12-30(35-19-25)36-31(38)27-16-22(21-6-5-14-33-18-21)20-37(32(27)39)23-7-3-2-4-8-23/h2-20H,1H3,(H,35,36,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human Pyk2 by HTRF assay				Bioorg Med Chem Lett 19: 4924-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.084 BindingDB Entry DOI: 10.7270/Q2N017G2
					More data for this Ligand-Target Pair