BDBM50301542 4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide::CHEMBL569270
SMILES: CNc1cc(ncn1)-c1csc(n1)N(C)C(=O)c1ccc(F)cc1
InChI Key: InChIKey=UTPGRZGMQVAYAA-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50301542 (4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to human mGluR5 by PDSP assay | J Med Chem 56: 9146-55 (2013) Article DOI: 10.1021/jm4012017 BindingDB Entry DOI: 10.7270/Q22N53RS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50301542 (4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to human dopamine D2 receptor by PDSP assay | J Med Chem 56: 9146-55 (2013) Article DOI: 10.1021/jm4012017 BindingDB Entry DOI: 10.7270/Q22N53RS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50301542 (4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to human sigma-1 receptor by PDSP assay | J Med Chem 56: 9146-55 (2013) Article DOI: 10.1021/jm4012017 BindingDB Entry DOI: 10.7270/Q22N53RS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Homo sapiens (Human)) | BDBM50301542 (4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to human histamine H1 receptor by PDSP assay | J Med Chem 56: 9146-55 (2013) Article DOI: 10.1021/jm4012017 BindingDB Entry DOI: 10.7270/Q22N53RS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50301542 (4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to human TSPO receptor by PDSP assay | J Med Chem 56: 9146-55 (2013) Article DOI: 10.1021/jm4012017 BindingDB Entry DOI: 10.7270/Q22N53RS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM50301542 (4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to human 5-HT3 receptor by PDSP assay | J Med Chem 56: 9146-55 (2013) Article DOI: 10.1021/jm4012017 BindingDB Entry DOI: 10.7270/Q22N53RS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50301542 (4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assay | Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50301542 (4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at human mGluR5 receptor expressed in CHO cells by FLIPR assay | Bioorg Med Chem Lett 19: 5464-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.097 BindingDB Entry DOI: 10.7270/Q2W66KTT | |||||||||||
More data for this Ligand-Target Pair |