BDBM50301647 CHEMBL568337::trans-N-(5-(4-fluorophenyl)pyrimidin-2-yl)-7'-oxo-7'H-spiro[cyclohexane-1,5'-furo[3,4-b]pyridine]-4-carboxamide

SMILES: Fc1ccc(cc1)-c1cnc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2ncccc32)nc1

InChI Key: InChIKey=GHWICCMCRSKETJ-CWSKOGRWSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50301647   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuropeptide Y receptor type 5 ( NPY Y5) (Homo sapiens (Human))	BDBM50301647 (CHEMBL568337 | trans-N-(5-(4-fluorophenyl)pyrimidi...) Show SMILES Fc1ccc(cc1)-c1cnc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2ncccc32)nc1 |r,wU:17.21,wD:14.14,(5.59,-24.52,;4.26,-23.75,;2.92,-24.52,;1.59,-23.76,;1.59,-22.21,;2.92,-21.44,;4.25,-22.2,;.26,-21.45,;-1.08,-22.22,;-2.41,-21.45,;-2.4,-19.91,;-3.73,-19.14,;-5.07,-19.91,;-6.4,-19.14,;-5.07,-21.45,;-6.4,-22.22,;-6.4,-23.76,;-5.07,-24.53,;-3.74,-23.76,;-3.74,-22.22,;-4.15,-25.78,;-5.05,-27.04,;-4.57,-28.5,;-6.53,-26.57,;-7.87,-27.34,;-9.21,-26.57,;-9.2,-25.02,;-7.87,-24.25,;-6.54,-25.01,;-1.08,-19.13,;.25,-19.9,)| Show InChI InChI=1S/C23H19FN4O3/c24-17-5-3-14(4-6-17)16-12-26-22(27-13-16)28-20(29)15-7-9-23(10-8-15)18-2-1-11-25-19(18)21(30)31-23/h1-6,11-13,15H,7-10H2,(H,26,27,28,29)/t15-,23-	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk cells				Bioorg Med Chem Lett 19: 5436-9 (2009) Article DOI: 10.1016/j.bmcl.2009.07.103 BindingDB Entry DOI: 10.7270/Q27D2V6Q
					More data for this Ligand-Target Pair