BDBM50302160 6-(piperazin-1-yl)-2-(2-(2-(trifluoromethyl)phenoxy)ethyl)pyridazin-3(2H)-one::CHEMBL569342
SMILES: FC(F)(F)c1ccccc1OCCn1nc(ccc1=O)N1CCNCC1
InChI Key: InChIKey=HKGGAOLOQBKMKY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50302160 (6-(piperazin-1-yl)-2-(2-(2-(trifluoromethyl)phenox...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 424 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]meselurgine from human recombinant 5HT2C receptor expressed in Swiss mouse 3T3 cells by SPA | Bioorg Med Chem Lett 19: 5791-5 (2009) Article DOI: 10.1016/j.bmcl.2009.07.136 BindingDB Entry DOI: 10.7270/Q2X0674Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50302160 (6-(piperazin-1-yl)-2-(2-(2-(trifluoromethyl)phenox...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 19: 5791-5 (2009) Article DOI: 10.1016/j.bmcl.2009.07.136 BindingDB Entry DOI: 10.7270/Q2X0674Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50302160 (6-(piperazin-1-yl)-2-(2-(2-(trifluoromethyl)phenox...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 19: 5791-5 (2009) Article DOI: 10.1016/j.bmcl.2009.07.136 BindingDB Entry DOI: 10.7270/Q2X0674Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50302160 (6-(piperazin-1-yl)-2-(2-(2-(trifluoromethyl)phenox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Agonist activity at human recombinant 5HT2A receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 19: 5791-5 (2009) Article DOI: 10.1016/j.bmcl.2009.07.136 BindingDB Entry DOI: 10.7270/Q2X0674Z | |||||||||||
More data for this Ligand-Target Pair |